Hot Start OmniTaq 2 is a mixture of OmniTaq 2 and a reversibly binding ssDNA aptamer.
OmniTaq 2 DNA polymerase is a mutant of Taq polymerase that provides 2-3x faster PCR and some inhibition-resistance.
The aptamer forms a hairpin and binds to the active site of the polymerase at sub-cycling temperatures, inactivating the enzyme and preventing spurious amplification. The aptamer is released at the first melt step, allowing full enzyme activity.
Please note that Hot Start OmniTaq 2 is not yet optimized for use in RT-PCR or RT-LAMP.